نتایج جستجو برای: nasal immunization

تعداد نتایج: 77445  

Journal: :nanomedicine journal 0
seyedeh mahnaz karimi school of pharmacy, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) mojtaba sankian faculty of medicine and immunology research center, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) farzad khademi antimicrobial resistance research center, department of medical bacteriology and virology, qaem university hospital, school of medicine, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) mohsen tafaghodi nanotechnology research center, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

objective(s): an efficient vaccine against tb is an urgent need. tb peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. the main purpose of the present study was to determine the potential of cht based nps containing esat-6 antigen of m. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...

Journal: :Infection and immunity 2001
L M Hodge M Marinaro H P Jones J R McGhee H Kiyono J W Simecka

The purpose of the present study was to determine the extent of immunologic responses, particularly immunopathologic responses, within the upper and lower respiratory tracts after intranasal immunization using the mucosal adjuvant cholera toxin (CT). BALB/c mice were nasally immunized with influenza virus vaccine combined with CT. The inclusion of the mucosal adjuvant CT clearly enhanced genera...

Journal: :iranian journal of pharmaceutical research 0
m tafaghodi sa sajadi tabassi mr jaafari

in induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (malt) m cells. in this study, we determined the systemic and mucosal immune responses in rabbits following intranasal immunization of tetanus toxoid tt and cpg-odn encapsulated within plga nanos...

Journal: :Journal of dental research 2007
K Miyachi K Ishihara R Kimizuka K Okuda

One major pathogenic factor of Porphyromonas gingivalis is Arg-gingipain (Rgp), an arginine-specific cysteine proteinase. To clarify the effect of rgpA DNA vaccine, we immunized BALB/c mice via the abdomen with a Gene Gun or via the nasal cavity weekly for 6 weeks. After immunization, the mice were challenged orally with P. gingivalis. Immunization elicited IgG responses against P. gingivalis i...

2015
Pengcheng LI Yunfeng LI Guoqing SHAO Qinghua YU Qian YANG

The aim of this study was to evaluate the immune responses to intranasal and intrapulmonary vaccinations with the attenuated Mycoplasma hyopneumoniae (Mhp) 168 strain in the local respiratory tract in pigs. Twenty-four pigs were randomly divided into 4 groups: an intranasal immunization group, an intrapulmonary immunization group, an intramuscular immunization group and a control group. The lev...

2013
Elena Pettini Gennaro Prota Annalisa Ciabattini Alessandro Boianelli Fabio Fiorino Gianni Pozzi Antonio Vicino Donata Medaglini

Primary T-cell activation at mucosal sites is of utmost importance for the development of vaccination strategies. T-cell priming after vaginal immunization, with ovalbumin and CpG oligodeoxynucleotide adjuvant as model vaccine formulation, was studied in vivo in hormone-synchronized mice and compared to the one induced by the nasal route. Twenty-four hours after both vaginal or nasal immunizati...

Journal: :iranian journal of basic medical sciences 0
mohsen tafaghodi school of pharmacy, mashhad university of medical sciences, mashhad, iran nanotechnology research center, mashhad university of medical sciences, mashhad, iran maryam eskandari school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) the immunoadjuvant potential of cross-linked dextran microspheres (cdm) as absorption enhancer and quillaja saponins (qs) as immunomodulator adjuvant was evaluated. materials and methods cdm loaded or tetanus-mixed toxoid (tt) or quillaja saponin (qs) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum igg and nasal lavage siga titers ...

Journal: :Infection and immunity 2006
Adam C Schaffer Robert M Solinga Jordan Cocchiaro Marta Portoles Kevin B Kiser Allison Risley Suzanne M Randall Viviana Valtulina Pietro Speziale Evelyn Walsh Timothy Foster Jean C Lee

Staphylococcus aureus is responsible for a wide range of infections, including soft tissue infections and potentially fatal bacteremias. The primary niche for S. aureus in humans is the nares, and nasal carriage is a documented risk factor for staphylococcal infection. Previous studies with rodent models of nasal colonization have implicated capsule and teichoic acid as staphylococcal surface f...

Journal: :Infection and immunity 1999
A Rudin G C Riise J Holmgren

Nasal vaccine delivery is superior to oral delivery in inducing specific immunoglobulin A (IgA) and IgG antibody responses in the upper respiratory tract. Although an antibody response in the nasal passages is important in protecting against primary colonization with lung pathogens, antibodies in the lungs are usually required as well. We immunized 15 male volunteers twice nasally or orally wit...

2011
Afton L. Thompson Herman F. Staats

Due to its potential as an effective, needle-free route of immunization for use with subunit vaccines, nasal immunization continues to be evaluated as a route of immunization in both research and clinical studies. However, as with other vaccination routes, subunit vaccines often require the addition of adjuvants to induce potent immune responses. Unfortunately, many commonly used experimental v...

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